Pat the boneless skinless chicken breasts dry with paper towels. In a small bowl, combine the kosher salt, garlic powder, onion powder, smoked paprika, black pepper, Italian seasoning, and chili powder (if using). Rub the olive oil over the chicken on all sides, then sprinkle the spice mixture evenly over the chicken, patting it in gently so it adheres.
2 pounds boneless skinless chicken breast, 1 tablespoon olive oil, 1 1/2 teaspoons kosher salt, 1 teaspoon garlic powder, 1 teaspoon onion powder, 1 teaspoon smoked paprika, 1/2 teaspoon black pepper, 1/2 teaspoon dried Italian seasoning, 1/2 teaspoon chili powder
Pour the chicken broth, lemon juice, and Worcestershire sauce into the Instant Pot. Stir briefly. This liquid will create the steam and pressure needed for cooking, so do not skip it.
1 cup low-sodium chicken broth, 1 tablespoon lemon juice, 1 teaspoon Worcestershire sauce
Place a trivet in the Instant Pot if you have one, or put the chicken directly in the liquid. Arrange the seasoned chicken breasts in a single layer as much as possible. Slight overlapping is fine, but avoid heavy stacking.
2 pounds boneless skinless chicken breast
Lock the Instant Pot lid in place and set the valve to “Sealing.” Cook on High Pressure: 8–10 minutes for fresh chicken breasts (8 minutes for thinner pieces, 10 minutes for thicker), or 12 minutes for frozen chicken breasts. If starting from frozen, season as best you can and plan to adjust seasoning after cooking if needed.
When the cook time is complete, let the pressure naturally release for 5–8 minutes. After that, carefully turn the valve to “Venting” to release any remaining steam before opening the lid.
Open the lid away from your face. Use an instant-read thermometer to check the thickest part of a chicken breast; it should read 165°F (74°C). If slightly under, set the lid back on and let the chicken sit in the hot liquid for a few minutes, or cook on High Pressure for 1–2 minutes more.
Transfer the cooked chicken breasts to a plate or cutting board and let them rest for about 5 minutes to allow the juices to redistribute. Slice the chicken for serving, or use two forks to shred it if you plan to use it in tacos, sandwiches, casseroles, or salads.
2 pounds boneless skinless chicken breast
For a quick sauce, turn the Instant Pot to Sauté and simmer the remaining cooking liquid for a few minutes until slightly reduced. Spoon it over the sliced or shredded chicken, or whisk in a teaspoon of cornstarch mixed with a teaspoon of water for a light gravy.